Cancer BiologybioRxivPreprint
Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells induces dedifferentiated liposarcoma potency
Yu Jin Kim, Minjung Sung, Dan Bi Yu…·Yoon-La Choi
This study shows that co-overexpression of MDM2 and CDK4 in transformed human BMSCs leads to dedifferentiated liposarcoma-like tumorigenesis by enhancing cell growth and migration while inhibiting adipogenic differentiation.
DOI 10.1101/293068