Persistent tailoring of MSC activation through genetic priming
Michael A. Beauregard, Guy C. Bedford, Daniel A. Brenner, Leonardo D. Sanchez Solis, Tomoki Nishiguchi, Abhimanyu, Santiago Carrero Longlax, Barun Mahata, Omid Veiseh, Pamela L. Wenzel, Andrew R. DiNardo, Isaac B. Hilton, Michael R. Diehl
This paper introduces a genetic priming method using IRF1 to sustainably enhance MSC potency and suppress immunogenicity compared to biochemical priming.
bioRxiv · Feb 1, 2024Bioengineering