Author

Leonardo D. Sanchez Solis

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Identified by ORCID

Leonardo D. Sanchez SolisiD3 papers · La Jolla Institute for Immunology

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Samuel A. MyersiD· 2 shared Abhimanyu AbhimanyuiD· 1 shared Andrew R. DiNardoiD· 1 shared Barun MahataiD· 1 shared Chris A. BenedictiD· 1 shared Daniel A. Brenner· 1 shared Erik EhingeriD· 1 shared Felipe Vásquez-CastroiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioinformatics

Samuel A. MyersORCID

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3 papers

Recent·Most cited

BioinformaticsBioinformatics AdvancesPeer-reviewedOct 29, 2026

PrEditR: A protein-centric platform for CRISPR-mediated base editor sgRNA design

Felipe Vásquez-Castro, Leonardo D. Sanchez Solis, Samuel A. Myers

PrEditR is a tool for designing sgRNAs for CRISPR-based base editors, allowing users to target specific amino acids and annotate resulting mutations.

DOI 10.1093/bioadv/vbag323

CRISPR screenexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 14, 2026

IL-27 induces a cytotoxic state in CD4+ T cells distinct from the Th1 lineage

Maria I. Matias, Rémi Marrocco, Kyle Magro…·Samuel A. Myers

This study identifies IL-27 as an inducer of a distinct CD4+ cytotoxic T cell program that differs from Th1 lineage.

DOI 10.64898/2026.09.08.746061

mouseproteomics

𝕏 PostBluesky

BioengineeringMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedAug 8, 2024

Persistent tailoring of MSC activation through genetic priming

Michael A. Beauregard, Guy C. Bedford, Daniel A. Brenner…·Michael R. Diehl

This paper introduces a genetic priming method using IRF1 to sustainably enhance MSC potency and suppress immunogenicity compared to biochemical priming.

8 citations

𝕏 PostBluesky