Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another
Wenye Li, Shoma Sato, Taichiro Takemura, Xiao Niu, Daniel Arnold, Maximilian Stanley Yo, Jarel Elgin Tolentino, Shigeru Fujita, Yusuke Kosugi, Nguyễn Thị Thu Thủy, Le Thi Quynh Mai, Nguyễn Thành Lương, Hidetaka S. Oshima, Kanata Matsumoto, Kazuhiro Sawada, , Kei Sato
This study identifies ACE2 diversity in horseshoe bats and shows bidirectional evolutionary shaping between ACE2 and sarbecovirus spike proteins.
bioRxiv · Oct 26, 2025 · PreprintMicrobiology