Author

Yusuke Kosugi

Institute of Medical Science, The University of Tokyo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Kei SatoiD· 6 shared Jarel Elgin TolentinoiD· 4 shared Jumpei ItoiD· 4 shared Keiya Uriu· 3 shared Maximilian Stanley Yo· 3 shared Shigeru FujitaiD· 3 shared Spyros LytrasiD· 3 shared Yu KakuiD· 3 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersMicrobiology

Kei SatoORCID

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Author profile →

6 papers

Recent·Most cited

Genetic diversity of pangolin coronaviruses reveals a key immuno-evasive substitution at spike residue 519

Maximilian Stanley Yo, Yu Kaku, Yusuke Kosugi, Jarel Elgin Tolentino, Daisuke Kuroda, Yunlong Cao, Kei Sato

The paper analyzes pangolin coronaviruses to identify a key immuno-evasive mutation at spike residue 519, similar to SARS-CoV-2, suggesting independent spillover events from bat reservoirs.

Journal of Virology · Jun 10, 2026Peer-reviewedMicrobiology

Humoral immunity induced by XEC monovalent vaccines against SARS-CoV-2 variants including XEC, LP.8.1, NB.1.8.1, XFG, and BA.3.2

Keiya Uriu, Yu Kaku, Yusuke Kosugi, Luo Chen, Naoya Itoh, Yoshifumi Uwamino, Hiroshi Fujiwara, Hironori Satoh, Kei Sato

This study evaluates the neutralizing antibody response induced by XEC-based monovalent vaccines against multiple SARS-CoV-2 variants, showing enhanced immunity against JN.1 subvariants compared to other variants.

Vaccine · Feb 10, 2026Peer-reviewedMicrobiology

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Shuhei Tsujino, Masumi Tsuda, Sayaka Deguchi, Jumpei Ito, Taha Y. Taha, Hesham Nasser, Lei Wang, Julia Rosecrans, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Mélanie Ott, Terumasa Ikeda, Kei Sato, Kazuo Takayama, , Miki Kawano

This study identifies the non-spike R204P mutation in the SARS-CoV-2 Omicron XEC variant as a driver of increased inflammation and pathogenicity through NF-κB activation.

Nature Communications · Dec 14, 2025Peer-reviewedMicrobiology

Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another

Wenye Li, Shoma Sato, Taichiro Takemura, Xiao Niu, Daniel Arnold, Maximilian Stanley Yo, Jarel Elgin Tolentino, Shigeru Fujita, Yusuke Kosugi, Nguyễn Thị Thu Thủy, Le Thi Quynh Mai, Nguyễn Thành Lương, Hidetaka S. Oshima, Kanata Matsumoto, Kazuhiro Sawada, , Kei Sato

This study identifies ACE2 diversity in horseshoe bats and shows bidirectional evolutionary shaping between ACE2 and sarbecovirus spike proteins.

bioRxiv · Oct 26, 2025 · PreprintMicrobiology

Molecular basis of sarbecovirus evolution and receptor tropism in natural hosts, potential intermediate hosts, and humans

Yusuke Kosugi, Kanata Matsumoto, Spyros Lytras, Arnon Plianchaisuk, Jarel Elgin Tolentino, Shigeru Fujita, Maximilian Stanley Yo, Chen Luo, Yoonjin Kim, Wataru Shihoya, Jumpei Ito, Osamu Nureki, Kei Sato

This study investigates the ACE2 tropism of sarbecoviruses across 17 mammals using pseudovirus assays, structural analysis, and phylogenetics to identify genetic factors influencing host range.

Cell Reports · Sep 1, 2025Peer-reviewedMicrobiology

Virological characteristics of the SARS-CoV-2 XEC variant

Yu Kaku, Kaho Okumura, Shusuke Kawakubo, Keiya Uriu, Chen Luo, Yusuke Kosugi, Yoshifumi Uwamino, MST Monira Begum, Sharee Leong, Terumasa Ikeda, Kenji Sadamasu, Hiroyuki Asakura, Mami Nagashima, Kazuhisa Yoshimura, Jumpei Ito, Kei Sato

This study analyzes the virological characteristics of the SARS-CoV-2 XEC variant, showing it has higher infectivity and immune evasion compared to KP.3.1.1, contributing to its higher reproductive number and potential dominance.

The Lancet Infectious Diseases · Nov 6, 2024Peer-reviewedMicrobiology