Hiroaki Akasaka

This study determines the cryo-EM structure of GPR30 with bicarbonate ions, identifies key residues for activation, and provides insights into G-protein coupling and drug development.

This study identifies ACE2 diversity in horseshoe bats and shows bidirectional evolutionary shaping between ACE2 and sarbecovirus spike proteins.

The paper reports the cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens and develops mutants with blue-shifted action spectra.

The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

The paper identifies a novel A3R-selective ligand and reveals structural insights into A3R activation, enabling structure-guided engineering of m6A-insensitive A3R for drug discovery.

This study reports the cryo-EM structure of the QRFP-GPR103-Gq complex, revealing unique binding mechanisms and insights into RF-amide peptide recognition.

The paper uses engineered G protein eGt with Nb35 to improve cryo-EM structure determination of GPCR-Gi complexes, achieving better map quality and reduced anisotropy.