ImmunologyThe Journal of ImmunologyPeer-reviewed
Chitinase 3-like-1 (CHI3L1) Inhibits Innate Anti-Tumor and Tissue Remodeling ImmuneResponses by Regulating CD47-SIRPα and CD24-Siglec10-Mediated Phagocytosis
Bing Ma, Suchitra Kamle, Takayuki Sadanaga…·Jack Angel Elias
This study shows CHI3L1 inhibits macrophage phagocytosis by modulating CD47-SIRPα and CD24-Siglec10 pathways, contributing to immune evasion in cancer and COPD.
12 citations