Evolutionary BiologybioRxiv
Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multi-drug resistance
Stefany Moreno-Gamez, Alison L Hill, Daniel I.S. Rosenbloom…·Pleuni Pennings
The paper models how imperfect drug penetration creates spatial monotherapy, accelerating multi-drug resistance evolution in infections.
DOI 10.1073/pnas.1424184112