Highly-efficient Cas9-mediated transcriptional programming
Alejandro Chavez, Jonathan Scheiman, Suhani Vora, Benjamin W Pruitt, Marcelle Tuttle, Eswar Iyer, Samira Kiani, Christopher D Guzman, Daniel J. Wiegand, Dimtry Ter-Ovanesyan, Jonathan L Braff, Noah Davidsohn, Ron Weiss, John Aach, Collins J Collins, George M Church
This study develops a highly efficient Cas9-based transcriptional activator, VPR-Cas9, capable of activating multiple genes and promoting neuronal differentiation from iPSCs.
bioRxiv · Dec 20, 2014Synthetic Biology