Author

Eswar Iyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:large language model· 1 Research Focus:perturbation response prediction· 1 Assay:protein sequence· 1

Frequent Co-Authors

Alejandro ChaveziD· 1 shared Benjamin W Pruitt· 1 shared Christopher D Guzman· 1 shared Collins J Collins· 1 shared Daniel J. Wiegand· 1 shared Dimtry Ter-Ovanesyan· 1 shared George M Church· 1 shared Jigar Doshi· 1 shared

Activity by Year

2014-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperSynthetic Biology

Alejandro ChavezORCID

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Author profile →

2 papers

Recent·Most cited

Aiki-GeNano: Multi-Stage Preference Optimization for Generative Design of Developable Nanobodies

Radheesh Sharma Meda, Jigar Doshi, Eswar Iyer, Shankar Shastry, Venkatesh P. Mysore

Aiki-GeNano improves nanobody design by integrating developability signals into training, enhancing thermal stability and reducing liabilities while preserving humanness.

bioRxiv · May 1, 2026 · PreprintBioinformatics

Highly-efficient Cas9-mediated transcriptional programming

Alejandro Chavez, Jonathan Scheiman, Suhani Vora, Benjamin W Pruitt, Marcelle Tuttle, Eswar Iyer, Samira Kiani, Christopher D Guzman, Daniel J. Wiegand, Dimtry Ter-Ovanesyan, Jonathan L Braff, Noah Davidsohn, Ron Weiss, John Aach, Collins J Collins, George M Church

This study develops a highly efficient Cas9-based transcriptional activator, VPR-Cas9, capable of activating multiple genes and promoting neuronal differentiation from iPSCs.

bioRxiv · Dec 20, 2014Synthetic Biology