Author

John Aach

Primary ORCID profile (0000-0001-7111-9541 · 9 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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John AachiD9 papers · Harvard University

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:genome assembly· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alejandro ChaveziD· 1 shared Alexandra GonzalesiD· 1 shared Barry L. Wanner· 1 shared Benjamin W Pruitt· 1 shared Cameron L. GardneriD· 1 shared Christopher D Guzman· 1 shared Christopher J. Gregg· 1 shared Collins J Collins· 1 shared

Activity by Year

2014-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSynthetic Biology

Alejandro ChavezORCID

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2 papers

Recent·Most cited

Assembly of Radically Recoded E. coli Genome Segments

Julie E. Norville, Cameron L. Gardner, Eduardo Aponte, Conor K. Camplisson, Alexandra Gonzales, David K. Barclay, Katerina A. Turner, Victoria Longe, Maria Mincheva, Jun Teramoto, Kento Tominaga, Ryota Sugimoto, James E. DiCarlo, Marc Guell, Eriona Hysolli, , George M. Church

This paper introduces CAGE 2.0, a platform for scarless assembly of recoded E. coli genome segments, enabling efficient and safe genome engineering.

bioRxiv · Aug 31, 2016 · PreprintSynthetic Biology

Highly-efficient Cas9-mediated transcriptional programming

Alejandro Chavez, Jonathan Scheiman, Suhani Vora, Benjamin W Pruitt, Marcelle Tuttle, Eswar Iyer, Samira Kiani, Christopher D Guzman, Daniel J. Wiegand, Dimtry Ter-Ovanesyan, Jonathan L Braff, Noah Davidsohn, Ron Weiss, John Aach, Collins J Collins, George M Church

This study develops a highly efficient Cas9-based transcriptional activator, VPR-Cas9, capable of activating multiple genes and promoting neuronal differentiation from iPSCs.

bioRxiv · Dec 20, 2014Synthetic Biology