MicrobiologybioRxiv
Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor cancer therapy
Steven Klupt, Kyong Tkhe Fam, Xing Zhang…·Howard C Hang
This study identifies SagA as essential for E. faecium growth, cell separation, and immune checkpoint inhibitor cancer therapy, showing its role in muropeptide production and NOD2 activation.
DOI 10.7554/elife.95297.3