Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease
Yiyi Zhu, Danjie Yang, jiayi chen, qi wang, Weijie Xiong, jingyu wang, hui chen, Alexei Verkhratsky, Chenju Yi
The paper identifies MFSD2A loss in hippocampal endothelial cells as an early stage-specific factor contributing to BBB disruption in Alzheimer's disease and shows that restoring MFSD2A can mitigate pathology and cognitive deficits.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience