Author

Jiayi Chen

Sun Yat-sen University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexei VerkhratskyiD· 1 shared Anirban RoyiD· 1 shared Anqi ZhouiD· 1 shared Ashok KumariD· 1 shared Bao Xue· 1 shared Bradley K. McConnelliD· 1 shared Chenju YiiD· 1 shared Chin‐Yo LiniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperNeuroscience

Alexei VerkhratskyORCID

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Author profile →

3 papers

Recent·Most cited

Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease

Yiyi Zhu, Danjie Yang, jiayi chen, qi wang, Weijie Xiong, jingyu wang, hui chen, Alexei Verkhratsky, Chenju Yi

The paper identifies MFSD2A loss in hippocampal endothelial cells as an early stage-specific factor contributing to BBB disruption in Alzheimer's disease and shows that restoring MFSD2A can mitigate pathology and cognitive deficits.

bioRxiv · Oct 8, 2026 · PreprintNeuroscience

Overexpression of miR-424(322)/-503 induces severe dilated cardiomyopathy by regulating the fatty acid oxidation gene expression program

Shreesti Shrestha, Jiayi Chen, Xiaopeng Shen, Rui Liang, Jahnvi Rajput, Marcello Tosso, Hoang Vu, Anirban Roy, Chin‐Yo Lin, Ryan L. Boudreau, Ashok Kumar, Bradley K. McConnell, Yu Liu

This study shows that overexpression of miR-424(322)/-503 in the heart causes severe dilated cardiomyopathy by disrupting fatty acid oxidation and metabolic function.

bioRxiv · Aug 18, 2026 · PreprintMolecular Biology

Discovery of resistance-resilient quinoline papain-like protease inhibitors through topology-constrained molecular generative design

Yongzhi Lu, Ting Ran, Qi Yang, Guihua Zhang, Jiayi Chen, Peiqi Zhou, Wenqi Li, Minyuan Xu, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, , Jinsai Shang

This paper discovers a novel quinoline-based PLpro inhibitor, GZNL-2016, that remains effective against drug-resistant SARS-CoV-2 variants like Omicron BA.5 and XBB.1.

bioRxiv · Sep 7, 2024 · PreprintMicrobiology