GenomicsbioRxivPreprint
Crowdsourcing: Spatial clustering of low-affinity binding sites amplifies in vivo transcription factor occupancy
Justin Malin, Daphne Ezer, Xiaoyan Ma…·Sridhar Hannenhalli
The paper shows that spatial clustering of low-affinity TF binding sites increases their in vivo occupancy through cooperative effects, with tissue-specific scaling and motif-dependent impacts.