NeuroscienceMolecular NeurodegenerationPeer-reviewed
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Jace Jones-Tabah, Kathy He, Nathan C. Karpilovsky…·Edward A. Fon
This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.
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