Author

Darshan V Trivedi

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Biochemistry· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

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James A Spudich· 1 shared Kathleen M Ruppel· 1 shared Saswata S Sarkar· 1 shared Shirley Sutton· 1 shared Suman Nag· 1 shared

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2016-2016 · peak 1/yr

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1 shared paperBiochemistry

James A Spudich

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1 paper

Recent·Most cited

BiochemistrybioRxivJul 24, 2016

Beyond the myosin mesa: a potential unifying hypothesis on the underlying molecular basis of hyper-contractility caused by a majority of hypertrophic cardiomyopathy mutations

Suman Nag, Darshan V Trivedi, Saswata S Sarkar…·James A Spudich

This paper proposes a unifying hypothesis that hypertrophic cardiomyopathy mutations increase functionally accessible myosin heads in the sarcomere, leading to hyper-contractility.

DOI 10.1038/nsmb.3408

humanproteomics

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