Author

David A. Jaffe

Thomas Jefferson University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:rat· 3 Assay:behavioral assay· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:mouse· 1

Frequent Co-Authors

Angelo C. LeporeiD· 4 shared Megan A. LyttleiD· 4 shared Lan ChengiD· 3 shared Pauline Michel‐FlutotiD· 3 shared Samantha J. ThomasiD· 3 shared Shuxin LiiD· 3 shared Angela Harbeck· 2 shared George M. SmithiD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Angelo C. LeporeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Recruitment of intrasegmental and propriospinal interneuron networks of forelimb motor circuitry in chronic cervical contusion spinal cord injury

Kallon Crowther, Angela Harbeck, Mackenzie Middlesworth, Morgan Bosch, Megan A. Lyttle, Claire MacGibbon, David A. Jaffe, Pauline Michel-Flutot, Evan Fitchett, Shuxin Li, Angelo C. Lepore

This study shows that PTEN inhibition improves forelimb motor recovery and circuit remodeling in chronic cervical SCI by enhancing spinal interneuron network recruitment and synaptic input.

bioRxiv · Nov 4, 2026 · PreprintNeuroscience

Intrasegmental and propriospinal pre-phrenic interneuron circuitry in intact CNS and following cervical spinal cord injury

Pauline Michel‐Flutot, Angela Harbeck, Lan Cheng, Khalil Rust, Megan A. Lyttle, Samantha J. Thomas, David A. Jaffe, Kallon Crowther, Gabriela Daszewska-Smith, George M. Smith, Shuxin Li, Angelo C. Lepore

The paper maps pre-phrenic interneuron (PP-IN) connectivity to phrenic motor neurons in uninjured and injured spinal cord, revealing intrasegmental and propriospinal pathways and their plasticity after injury.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

Neuronal EphB2 signaling drives persistent neuropathic pain following spinal cord injury

Nicolette M. Heinsinger, David A. Jaffe, Kolluru D. Srikanth, Megan A. Lyttle, Madison S. Smith, Samantha J. Thomas, Brittany A. Charsar, Lan Cheng, Pauline Michel‐Flutot, Rachel E. Cain, Jaime L. Watson, Duran Bao, Jia Fan, Aditi Falnikar, Wei Zhou, , Angelo C. Lepore

This study identifies EphB2 signaling in neurons as a mechanism maintaining neuropathic pain after spinal cord injury.

bioRxiv · Apr 22, 2026 · PreprintNeuroscience

PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury

Pauline Michel‐Flutot, Lan Cheng, Samantha J. Thomas, Brianna Lisi, Harrison Schwartz, Sandy Lam, Megan A. Lyttle, David A. Jaffe, George M. Smith, Shuxin Li, Megan C. Wright, Angelo C. Lepore

This study shows that PTEN inhibition promotes partial diaphragm function recovery and axon growth in chronic cervical spinal cord injury, while PTPσ inhibition does not.

bioRxiv · Jan 10, 2024Neuroscience