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David R. Kovar

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Biophysics· 1

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Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

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Gregory A. VothiD· 1 shared Margaret L. Gardel· 1 shared Vilmos Zsolnay· 1 shared

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Gregory A. VothORCID

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1 paper

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BiophysicsbioRxivJun 26, 2023

Cracked actin filaments as mechanosensitive receptors

Vilmos Zsolnay, Margaret L. Gardel, David R. Kovar, Gregory A. Voth

This paper uses molecular dynamics simulations to show that mechanical strain on actin filaments creates a metastable cracked conformation, which serves as a binding site for LIM domain proteins.

DOI 10.1016/j.bpj.2024.06.014

mechanistic / dynamical modelprotein folding & dynamics

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