Author

Deepika Sharma

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Developmental Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Courtney M. KarneriD· 3 shared Abigail P. LeinrothiD· 2 shared Anthony J. MirandoiD· 2 shared Jason T. LongiD· 2 shared Matthew J. HiltoniD· 2 shared Amy B. Hair· 1 shared Brian Scottoline· 1 shared Caden W. SweetiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersDevelopmental Biology

Courtney M. KarnerORCID

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Author profile →

4 papers

Recent·Most cited

Transmural Single-Nucleus Transcriptomics Nominates Candidate Disease Programs in Human Necrotizing Enterocolitis

Mickael F. Meyer, Caden W. Sweet, Keith Breau, Joseph Burclaff, R. Jarrett Bliton, Hailey M. Dodson, Gabrielle Cannon, Pauline Bougaran, Vikram Puri, Lauren C. Frazer, Lauren R. Bolzan, Catherine R. Rizzuto, Danielle E. Sklar, Corey M. Jania, Gergely D. Mozes, , Scott T. Magness

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

bioRxiv · Nov 4, 2026 · PreprintPathology

Hypertrophic Chondrocytes Serve as a Reservoir for Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development

Jason T. Long, Abigail P. Leinroth, Yihan Liao, Yinshi Ren, Anthony J. Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn S.E. Cheah, Courtney M. Karner, Matthew J. Hilton

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.

eLife · Feb 18, 2022Peer-reviewedDevelopmental Biology

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

Deepika Sharma, Yilin Yu, Leyao Shen, Guofang Zhang, Courtney M. Karner

This study identifies Slc1a5 as essential for osteoblast differentiation and bone development by facilitating glutamine and asparagine import in mice.

eLife · Oct 14, 2021Peer-reviewedDevelopmental Biology

HES1 is a critical mediator of the SHH-GLI3 axis in regulating digit number

Deepika Sharma, Anthony J. Mirando, Abigail P. Leinroth, Jason T. Long, Courtney M. Karner, Matthew J. Hilton

The paper identifies HES1 as a critical mediator of the SHH-GLI3 axis in regulating digit number, showing its role in inducing polydactyly and modulating cell proliferation and chondrogenesis.

bioRxiv · Jun 17, 2020 · PreprintDevelopmental Biology