Caden W. Sweet

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

This study shows SOX9 elongates G1 phase in intestinal stem cells, enhancing injury resistance and stemness, and identifies the INK4A-Rb pathway as a mediator.

The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

The paper identifies EPIREGULIN as a niche factor that enables spatial organization in human intestinal organoids, mimicking the native intestine's structure and gene expression.

This study uses scRNA-seq to analyze human intestinal development, identifying cell sources of niche factors and their functional roles in stem cell maintenance.

This study enhances the co-differentiation of intestinal organoids with endothelial cells, showing they share an intestinal-specific transcriptional signature with native cells.