Joseph Burclaff

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study shows SOX9 elongates G1 phase in intestinal stem cells, enhancing injury resistance and stemness, and identifies the INK4A-Rb pathway as a mediator.

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

This study shows that deleting estrogen receptor alpha in colonic epithelial cells protects female mice from inflammation but causes hyper-proliferation in males.

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

This paper develops an efficient electroporation method for transgenesis and gene editing in human intestinal stem cells, achieving high efficiency and viability.