Cell BiologyNature CommunicationsPeer-reviewed
Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition
Wei Yang, Shaobo Cong, Ruoyao Li…·Wenjing Qi
The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.
DOI 10.1038/s41467-025-61626-z