Elicitation of stem-directed antibodies in rhesus macaques by a conventional hemagglutinin immunogen
Shuqin Gu, Joel Finney, Kan Luo, Sarah M. Valencia, Dieter Mielke, Tarra A. Von Holle, DJ Marshall, Robert Parks, Laura L. Sutherland, Richard M. Scearce, Kevin J. Wiehe, Sampa Santra, Summer Harris, Jacquelyn DuVall, Chelsea D. Landon, , Michael Anthony Moody
This study shows that a conventional H1 HA trimer vaccine elicits stem-directed antibodies in rhesus macaques that provide broad protection against H1N1 and H5N1 influenza.
bioRxiv · Jul 21, 2026 · PreprintImmunology