Aaron G. Schmidt

The paper develops scalable cell-free protein synthesis platforms to generate single-cell RNA-sequencing data on immune cell responses to cytokines and other signals, enabling functional discovery and drug target prioritization.

This study identifies Rabgef1 as a regulator of gasdermin pore formation by controlling membrane cholesterol, showing cholesterol depletion restores pyroptosis in cancer cells and tumors.

A hyperglycosylated influenza neuraminidase immunogen reshapes humoral immunity and elicits antibodies targeting a conserved tetramer-interface epitope.

This study shows that a conventional H1 HA trimer vaccine elicits stem-directed antibodies in rhesus macaques that provide broad protection against H1N1 and H5N1 influenza.

The paper shows human ISGs can restrict bacterial phage replication, revealing conserved antiviral mechanisms across kingdoms.

The paper develops a yeast surface display library of bat antibodies to study humoral immunity to H9 influenza hemagglutinin, revealing structural and functional characteristics of bat antibodies.

This paper introduces a modular immunogen platform that displays multiple hemagglutinin subtypes and elicits cross-reactive immune responses against influenza subtypes not included in the immunogen.

This study investigates the role of lupus-associated innate receptors in the extrafollicular development of autoreactive B cells using adoptive transfer and time-stamped analysis in a mouse model.

The paper uses neuraminidase-on-a-string nanoparticles to show that antigenic distance between strains influences the breadth and cross-reactivity of humoral immunity.

The paper identifies conserved sites on influenza H1 and H3 hemagglutinin recognized by human antibodies and characterizes their neutralization potential and escape pathways.

The paper assesses viral escape from imprinted broad antibody responses using deep mutational scanning of clonal antibody lineages against influenza HA epitopes, showing escape is possible through epistatic networks in drifted strains.

This paper introduces a high-throughput method for screening antibody neutralization using droplet arrays, demonstrating scalable functional antibody data collection against viral diseases.

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

This study characterizes the serological repertoire of SARS-CoV-2 convalescent patients, revealing a high prevalence of iso-RBD antibodies that do not recognize prefusion-stabilized S, and shows that vaccination with prefusion-stabilized S reduces their prevalence.