Author

E. A. Shoubridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Janer· 2 shared A.-C. Gingras· 2 shared H. Antonicka· 2 shared M. J. Aaltonen· 2 shared W. Weraarpachai· 2 shared Z.-Y. Lin· 2 shared A. Zidell· 1 shared C. Bonnemann· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Janer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasis

A. Janer, J. L. Morris, M. Krols, H. Antonicka, M. J. Aaltonen, Z.-Y. Lin, A.-C. Gingras, J. Prudent, E. A. Shoubridge

This study identifies ESYT1 as a key protein tethering ER and mitochondria at MERCs, showing its role in calcium and lipid homeostasis.

bioRxiv · Nov 14, 2022 · PreprintCell Biology

SPTLC1 variants associated with childhood onset amyotrophic lateral sclerosis produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

M. A. Lone, M. J. Aaltonen, A. Zidell, H. F. Pedro, J. A. M. Saute, S. Mathew, P. Mohassel, C. Bonnemann, E. A. Shoubridge, T. Hornemann

The paper shows that SPTLC1 variants causing childhood ALS disrupt ORMDL interactions, leading to altered sphingolipid synthesis and distinct lipid signatures, modifiable by L-serine availability.

bioRxiv · Apr 29, 2022 · PreprintBiochemistry

A CHCHD10 variant causing ALS elicits an unfolded protein response through the IRE1/XBP1 pathway

I. R. Straub, W. Weraarpachai, E. A. Shoubridge

This study shows that a CHCHD10 variant causes ALS by triggering an unfolded protein response via the IRE1/XBP1 pathway, leading to metabolic and stress-related changes in patient cells.

bioRxiv · May 5, 2020 · PreprintCell Biology

A high-density human mitochondrial proximity interaction network.

H. Antonicka, Z.-Y. Lin, A. Janer, W. Weraarpachai, A.-C. Gingras, E. A. Shoubridge

This paper creates a high-resolution human mitochondrial proximity interaction network using BioID, identifying 1465 proteins and 15626 interactions, revealing sub-compartment organization and functional modules.

bioRxiv · Apr 1, 2020Cell Biology

LONP1 is required for maturation of a subset of mitochondrial proteins and its loss elicits an integrated stress response

O. Zurita Rendon, E. A. Shoubridge

This study shows that LONP1 is necessary for maturing specific mitochondrial proteins and its absence causes stress response activation and mitochondrial dysfunction.

bioRxiv · Apr 23, 2018Biochemistry