Author

Z.-Y. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A.-C. Gingras· 4 shared A. Janer· 2 shared E. A. Shoubridge· 2 shared H. Antonicka· 2 shared A. Carpenter· 1 shared B. Cimini· 1 shared C. Fullenkamp· 1 shared C. Reno· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersCell Biology

A.-C. Gingras

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pervasive mislocalization of pathogenic coding variants underlying human disorders

J. Lacoste, M. Haghighi, S. Haider, Z.-Y. Lin, D. Segal, C. Reno, W. W. Qian, X. Xiong, H. Shafqat-Abbasi, P. Ryder, R. Senft, B. Cimini, F. Roth, M. Calderwood, D. Hill, , M. Taipale

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

bioRxiv · Sep 5, 2023Cell Biology

ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasis

A. Janer, J. L. Morris, M. Krols, H. Antonicka, M. J. Aaltonen, Z.-Y. Lin, A.-C. Gingras, J. Prudent, E. A. Shoubridge

This study identifies ESYT1 as a key protein tethering ER and mitochondria at MERCs, showing its role in calcium and lipid homeostasis.

bioRxiv · Nov 14, 2022 · PreprintCell Biology

Targeting Reductive Metabolic Shifts by T315I Mutation in BCR-ABL Myeloid Leukemia for Therapy

C. Y. Huang, Y.-H. Chung, S.-Y. Wu, H.-Y. Wang, Z.-Y. Lin, T.-J. Yang, J.-M. Feng, C.-M. Hu, Z.-F. Chang

This study identifies metabolic shifts in T315I-Bcr-Abl CML and shows that combining JMF4073 with UK-5099 eradicates the disease in vivo.

bioRxiv · Mar 22, 2022 · PreprintCancer Biology

TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex

N. Merritt, K. Garcia, D. Rajendran, Z.-Y. Lin, X. Zhang, K. Mitchell, N. Borcherding, C. Fullenkamp, M. Chimenti, A.-C. Gingras, K. Harvey, M. R. Tanas

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

bioRxiv · Sep 7, 2020Cancer Biology

A high-density human mitochondrial proximity interaction network.

H. Antonicka, Z.-Y. Lin, A. Janer, W. Weraarpachai, A.-C. Gingras, E. A. Shoubridge

This paper creates a high-resolution human mitochondrial proximity interaction network using BioID, identifying 1465 proteins and 15626 interactions, revealing sub-compartment organization and functional modules.

bioRxiv · Apr 1, 2020Cell Biology