Author

M. A. Lone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. DiLuca· 1 shared A. T. J. Peter· 1 shared A. Zidell· 1 shared C. Bonnemann· 1 shared C. Gehin· 1 shared E. A. Shoubridge· 1 shared G. D'Angelo· 1 shared H. F. Pedro· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. DiLuca

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2 papers

Recent·Most cited

Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism.

S. Srinivasan, A. DiLuca, A. T. J. Peter, C. Gehin, M. A. Lone, T. A. Hornemann, G. D'Angelo, S. Vanni

This study uses molecular simulations to show that lipid transfer domains (LTDs) from different LTP families share conserved dynamical features that correlate with their functional mechanism.

bioRxiv · Apr 11, 2023 · PreprintBiophysics

SPTLC1 variants associated with childhood onset amyotrophic lateral sclerosis produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

M. A. Lone, M. J. Aaltonen, A. Zidell, H. F. Pedro, J. A. M. Saute, S. Mathew, P. Mohassel, C. Bonnemann, E. A. Shoubridge, T. Hornemann

The paper shows that SPTLC1 variants causing childhood ALS disrupt ORMDL interactions, leading to altered sphingolipid synthesis and distinct lipid signatures, modifiable by L-serine availability.

bioRxiv · Apr 29, 2022 · PreprintBiochemistry