PathologybioRxiv
Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis
E. Christodoulou-Vafeiadou, C. Geka, L. Ntari…·G. Kollias
This paper characterizes a transmembrane TNF-driven mouse model of spondyloarthritis, showing ectopic bone formation, systemic bone loss, and comorbid heart valve pathology, with early anti-TNF treatment reducing inflammation.