KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment
S. C. Callahan, M. Divenko, P. Barrodia, A. K. Singh, E. Arslan, Z. Liu, J. Yang, N. Anvar, M. Amit, T. Xie, S. Jiang, J. Schulz, M. Tang, J. N. Myers, K. Rai
This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.
bioRxiv · Sep 21, 2021 · PreprintCancer Biology