J. Schulz

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.

Pathogen-prey-predator relations of avian raptors during epizootics of highly pathogenic avian influenza virus HPAIV H5N1 (clade 2.3.4.4b) in Germany

The paper investigates the impact of HPAIV H5N1 on avian raptors during epizootics in Germany, finding they act as both indicators of the virus and victims, with mixed outcomes for their population stability.

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

Convolutional neural network approach for the automated identification of in cellulo crystals

This paper uses a convolutional neural network to automatically identify in cellulo crystals in living insect cells from bright field images.

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

High Enhancer Activity is an Epigenetic Feature of HPV Negative Atypical Head and Neck Squamous Cell Carcinoma

The paper identifies high enhancer activity in HPV-negative atypical HNSCC as linked to BET inhibitor resistance and upregulated signaling pathways.

H3K4me1-marked Enhancer Activation in Resistant Prostate Cancers Implicates SOX4 and MENIN Inhibition as Therapeutic Strategies

The paper identifies H3K4me1-marked enhancers in therapy-resistant prostate cancers and suggests SOX4 and MENIN inhibition as therapeutic strategies.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

Increased aerosol transmission for B.1.1.7 (alpha variant) over lineage A variant of SARS-CoV-2

This study shows that the B.1.1.7 variant of SARS-CoV-2 is more efficiently transmitted via aerosols than lineage A in Syrian hamsters.

THESEUS1 modulates cell wall stiffness and abscisic acid production in Arabidopsis thaliana

This study identifies THESEUS1 as a regulator of cell wall stiffness and abscisic acid production in Arabidopsis thaliana, linking cell wall integrity to turgor pressure and drought response.

ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys

ChAdOx1 NiV vaccination protects African green monkeys from lethal Nipah virus infection, preventing disease signs and viral replication.

Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

This study evaluates the immunogenicity of a low-dose prime-boost mRNA vaccine in non-human primates, finding limited antibody and T cell responses in some animals.

Western diet increases COVID-19 disease severity in the Syrian hamster

This study shows that a Western diet worsens COVID-19 outcomes in Syrian hamsters by increasing weight loss, lung damage, and systemic inflammation.

Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.

Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer

This study identifies enhancer subtypes in colorectal cancer through epigenomic analysis and proposes targeted therapeutic strategies based on these subtypes.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.