The RAG1 Ubiquitin Ligase Domain Enhances Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity
T. Burn, C. Miot, S. Gordon, E. Culberson, T. Diamond, P. Kreiger, K. Hayer, A. Bhattacharyya, J. Jones, C. Bassing, E. Behrens
This study shows that the RAG1 ubiquitin ligase domain enhances TCR gene assembly and selection, reducing autoimmune risk in mice.
bioRxiv · Jan 4, 2021 · PreprintImmunology