S. Gordon

Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages.

This study shows that loss of MARCO in macrophages leads to increased vomocytosis of Cryptococcus neoformans.

Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production

The paper shows that MARCO on alveolar macrophages reduces Ace expression and aldosterone production in male mice lungs.

Distinct adrenal gland macrophages regulate corticosteroid production

This study identifies two distinct adrenal macrophage subsets in mice and shows that foamy macrophages regulate corticosteroid production through cholesterol accumulation.

Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

This study shows that one-carbon metabolism is essential for Streptococcus pneumoniae virulence, while proline biosynthesis has a strain-dependent role in systemic infection.

Reciprocal regulation of TLR4, TLR3 and Macrophage Scavenger Receptor 1 regulates nonopsonic phagocytosis of the fungal pathogen Cryptococcus neoformans.

This study identifies MSR1 as a key receptor for nonopsonic phagocytosis of Cryptococcus neoformans and shows TLR4/MSR1 crosstalk in this process.

Tracking the Ancestry of Known and 'Ghost' Homeologous Subgenomes in Model Grass Brachypodium Polyploids

The paper identifies subgenomes in Brachypodium polyploids using phylogenomic methods and confirms the existence of ancestral genomes in polyploids.

The RAG1 Ubiquitin Ligase Domain Enhances Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

This study shows that the RAG1 ubiquitin ligase domain enhances TCR gene assembly and selection, reducing autoimmune risk in mice.

Functional succinate dehydrogenase deficiency and loss of ascorbic acid transporter SLC23A1 are pathognomonic adverse features of clear cell renal cancer

This paper identifies functional succinate dehydrogenase deficiency and loss of SLC23A1 as common adverse features in clear cell renal cell carcinoma, with implications for diagnosis and treatment.

Geographic mosaic of selection by avian predators on hindwing warning colour in a polymorphic aposematic moth

The paper shows that avian predator selection on warning coloration in moths varies geographically, with stronger positive frequency-dependent selection in monomorphic populations and weaker selection in polymorphic ones.

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

This study shows JUN activation in fibroblasts drives fibrosis and modulates immunity, with therapeutic potential through targeting IL-6, CD47, and PD-L1.

Insights into ancestry and adaptive evolution of the Mycobacterium tuberculosis complex from analysis of the emerging pathogen Mycobacterium riyadhense

This paper characterizes the genome of Mycobacterium riyadhense, showing it shares ancestry with Mycobacterium tuberculosis and provides insights into the evolutionary path of the MTBC.

Pneumococcal Colonisation is an Asymptomatic Event in Healthy Adults using an Experimental Human Colonisation Model.

This study investigates whether pneumococcal colonisation in healthy adults is symptomatic using an experimental challenge model, finding it asymptomatic regardless of bacterial density or viral co-colonisation.