The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2
N. Kozlova, D. Mennerich, A. Samoylenko, E. Y. Dimova, P. Koivunen, E. Biterova, K. Richter, A. Hassinen, S. Kellokumpu, A. Manninen, I. Miinalainen, V. Glumoff, L. Ruddock, L. Drobot, T. Kietzmann
This study identifies CIN85 as a novel binding partner of PHD2, showing it inhibits PHD2 activity and HIF degradation, promoting tumor growth in mice.
bioRxiv · Nov 20, 2018Biochemistry