Author

A. Manninen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G.-H. Wei· 3 shared Q. Zhang· 3 shared A. Ahtikoski· 2 shared M. H. Vaarala· 2 shared R. Devarajan· 2 shared T. Wenta· 2 shared X. Yang· 2 shared A. Hassinen· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

G.-H. Wei

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

DLL4-Notch3-WNT5B axis is a novel mediator of bi-directional pro-metastatic crosstalk between melanoma and lymphatic endothelial cells

S. Alve, S. Gramolelli, J. Jukonen, S. Juteau, A. Pink, A. Manninen, E. Monto, M. H. Lackman, O. Carpen, S. Karaman, P. Saharinen, K. Vaahtomeri, P. M. Ojala

bioRxiv · Apr 21, 2023 · PreprintCancer Biology

TEAD1 regulates ITGA1 and ITGA2 to control prostate cancer progression

S. P. Cruz, Q. Zhang, R. Devarajan, C. Paia, B. Luo, K. Zhang, J. Xia, A. Ahtikoski, M. H. Vaarala, T. Wenta, G.-H. Wei, A. Manninen

This study identifies TEAD1 as a regulator of ITGA1 and ITGA2 in prostate cancer, showing their loss promotes tumor progression via TGFβ1-driven EMT.

bioRxiv · Apr 12, 2023Cancer Biology

Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions

T. Wenta, A. Schmidt, Q. Zhang, R. Devarajan, P. Singh, X. Yang, A. Ahtikoski, M. H. Vaarala, G.-H. Wei, A. Manninen

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

bioRxiv · Nov 8, 2021Cancer Biology

Extensive germline-somatic interplay drives prostate cancer through HNF1B co-option of TMPRSS2-ERG

N. Giannareas, Q. Zhang, X. Yang, Y. Tian, P. Zhang, Y. Yang, A. Manninen, L. Wang, G.-H. Wei

This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.

bioRxiv · Sep 2, 2021 · PreprintCancer Biology

The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2

N. Kozlova, D. Mennerich, A. Samoylenko, E. Y. Dimova, P. Koivunen, E. Biterova, K. Richter, A. Hassinen, S. Kellokumpu, A. Manninen, I. Miinalainen, V. Glumoff, L. Ruddock, L. Drobot, T. Kietzmann

This study identifies CIN85 as a novel binding partner of PHD2, showing it inhibits PHD2 activity and HIF degradation, promoting tumor growth in mice.

bioRxiv · Nov 20, 2018Biochemistry