The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels
D. Mennerich, Y. Ashok, C. Vela-Rodriguez, H. I. Hentilä, M. Rall-Scharpf, L. Wiesmüller, R. Prunskaite-Hyyryläinen, L. Lehtiö, T. Kietzmann
This paper identifies a regulatory feedback loop between DTX3L and USP28 that modulates DNA double-strand break repair by controlling protein levels and repair pathway efficiency.
bioRxiv · Jan 30, 2023Biochemistry