BiochemistrybioRxiv
The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2
N. Kozlova, D. Mennerich, A. Samoylenko…·T. Kietzmann
This study identifies CIN85 as a novel binding partner of PHD2, showing it inhibits PHD2 activity and HIF degradation, promoting tumor growth in mice.
DOI 10.1158/0008-5472.can-18-3852