Translational T-box riboswitches bind tRNA by modulating conformational flexibility
E. Campos-Chavez, S. Paul, Z. Zhou, D. Alonso, A. R. Verma, J. Fei, A. Mondragon
This study uses single-molecule FRET to analyze the binding mechanism of the Mycobacterium tuberculosis IleS T-box riboswitch, revealing a two-step model and the role of specific sequences in conformational flexibility and tRNA recognition.
bioRxiv · Feb 2, 2024 · PreprintBiophysics