BiochemistrybioRxiv
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1
J. F. Thomas, M. I. Valencia-Sanchez, S. Tamburri…·K.-J. Armache
This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.