State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Leukemia Development
R. C. Rockne, S. Branciamore, J. Qi, D. Frankhouser, D. O'Meally, W.-K. Hua, G. J. Cook, L. Zhang, E. Carnahan, A. Marom, H. Wu, D. Maestrini, X. Wu, Y.-C. Yuan, Z. Liu, , G. Marcucci
The paper models leukemia transcriptome dynamics in a state-space to identify critical points that predict disease development.
bioRxiv · Jun 4, 2019 · PreprintCancer Biology