Cxcr4 desensitization is an essential regulatory mechanism controlling the extra-follicular B cell response.
N. Alouche, A. Bonaud, V. Rondeau, J. Nguyen, E. Cricks, N. Setterblad, M. Mahevas, K. Balabanian, M. Espeli
This study shows that CXCR4 desensitization is crucial for regulating B cell activation, plasma cell differentiation, and migration in the extra-follicular response.
bioRxiv · Feb 1, 2019 · PreprintImmunology