M. Espeli

Plasma cell heterogeneity is driven by type of immune challenge

This study identifies five plasma cell subsets in humans and mice, showing their heterogeneity is driven by immune challenge type and B cell origin.

Generation of natural killer and myeloid cells in a 3D artificial marrow organoid system

This paper develops a 3D artificial marrow organoid model to study NK and myeloid cell differentiation, showing improved immune receptor expression and drug response compared to 2D models.

CXCR4 signaling strength regulates hematopoietic multipotent progenitor fate through extrinsic and intrinsic mechanisms

This study shows that CXCR4 signaling strength influences hematopoietic multipotent progenitor fate through both extrinsic and intrinsic mechanisms, with implications for myeloid skewing in WHIM Syndrome.

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

Cxcr4 desensitization is an essential regulatory mechanism controlling the extra-follicular B cell response.

This study shows that CXCR4 desensitization is crucial for regulating B cell activation, plasma cell differentiation, and migration in the extra-follicular response.