Ectopic histone clipping in the mouse model of progressive myoclonus epilepsy
E. Daura, S. Tegelberg, M. Yoshihara, C. Jackson, F. Simonetti, K. Aksentjeff, S. Ezer, P. Hakala, S. Katayama, J. Kere, A.-E. Lehesjoki, T. Joensuu
This study identifies CSTB as a regulator of histone H3 tail clipping in NPCs and links its deficiency to epigenetic dysregulation and impaired mitochondrial function in a mouse model of progressive myoclonus epilepsy.
bioRxiv · Aug 21, 2020 · PreprintPathology