The negative adipogenesis regulator DLK1 is transcriptionally regulated by TIS7 (IFRD1) and translationally by its orthologue SKMc15 (IFRD2)
I. Vietor, D. Cikes, K. Piironen, T. Vasakou, D. Heimdoerfer, R. Gstir, M. D. Erlacher, I. Tancevski, P. Eller, E. Demetz, M. Hess, V. Kuhn, G. Degenhart, J. Rozman, M. Klingenspor, , L. A. Huber
This paper identifies two regulatory mechanisms, transcriptional and translational, by which TIS7 and SKMc15 control DLK1 levels, impacting adipogenesis and obesity resistance.
bioRxiv · Apr 3, 2023Cell Biology