L. A. Huber

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

This paper identifies two regulatory mechanisms, transcriptional and translational, by which TIS7 and SKMc15 control DLK1 levels, impacting adipogenesis and obesity resistance.

This study shows that lysosome positioning influences PLEKHG3 localization and protrusive activity, but protrusion changes can occur without PLEKHG3.

The paper shows that LAMTOR2 deletion in adipocytes causes insulin-independent AKT hyperphosphorylation, leading to increased glucose and fatty acid uptake and glycogen storage in brown adipose tissue.

The paper identifies novel factors for epithelial polarization and apical transport using a CRISPR screen in human intestinal epithelial cells.

The paper identifies complementary α-arrestin-Rsp5 complexes that regulate selective endocytosis of nutrient transporters based on amino acid availability.

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.