J. Rozman

Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

The negative adipogenesis regulator DLK1 is transcriptionally regulated by TIS7 (IFRD1) and translationally by its orthologue SKMc15 (IFRD2)

This paper identifies two regulatory mechanisms, transcriptional and translational, by which TIS7 and SKMc15 control DLK1 levels, impacting adipogenesis and obesity resistance.

Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection

This study examines SARS-CoV-2-specific T cell responses 12-months post-infection, finding durable responses with higher frequencies in those with severe acute illness.

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease