Author

E. Diers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. B. Frost· 2 shared A. Ciulli· 2 shared C. Kofink· 2 shared C. Whitworth· 2 shared M. Koegl· 2 shared N. Trainor· 2 shared V. Vetma· 2 shared W. Farnaby· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. B. Frost

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2 papers

Recent·Most cited

Confounding factors in targeted degradation of short-lived proteins

V. Vetma, L. C. Perez, J. Elias, A. Stingu, A. Kombara, T. Gmaschitz, N. Braun, T. Ciftci, G. Dahmann, E. Diers, T. Gerstberger, P. Greb, G. Kidd, C. Kofink, I. Puoti, , M. Koegl

This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.

bioRxiv · Feb 19, 2024Cancer Biology

Targeting cancer with small molecule pan-KRAS degraders

J. Popow, W. Farnaby, A. Gollner, C. Kofink, G. Fischer, M. Wurm, D. Zollman, A. Wijaya, N. Mischerikow, C. Hasenoehrl, P. Prokofeva, H. Arnhof, S. Arce-Solano, S. Bell, G. Boeck, , A. Ciulli

A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.

bioRxiv · Oct 24, 2023Pharmacology & Toxicology