Author

N. Braun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:electrophysiology· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Andersen· 2 shared A. B. Frost· 1 shared A. Ciulli· 1 shared A. Kombara· 1 shared A. Sinz· 1 shared A. Stingu· 1 shared C. B. Borg· 1 shared C. Ihling· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

J. Andersen

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3 papers

Recent·Most cited

Confounding factors in targeted degradation of short-lived proteins

V. Vetma, L. C. Perez, J. Elias, A. Stingu, A. Kombara, T. Gmaschitz, N. Braun, T. Ciftci, G. Dahmann, E. Diers, T. Gerstberger, P. Greb, G. Kidd, C. Kofink, I. Puoti, , M. Koegl

This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.

bioRxiv · Feb 19, 2024Cancer Biology

High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

N. Braun, S. Friis, C. Ihling, A. Sinz, J. Andersen, S. A. Pless

The paper develops a high-throughput method to study functional and pharmacological properties of ncAA-containing hASIC1a variants using automated patch-clamp.

bioRxiv · Nov 24, 2020Biophysics

Mechanism and site of action of big dynorphin on ASIC1a

C. B. Borg, N. Braun, S. A. Heusser, Y. Bay, D. Weis, I. Galleano, C. Lund, W. Tian, L. M. Haugaard-Kedstroem, E. P. Bennett, T. Lynagh, K. Stromgaard, J. Andersen, S. Pless

This study identifies the binding site and mechanism of big dynorphin on ASIC1a, revealing the acidic pocket as the interaction site and highlighting its potential for therapeutic development.

Proceedings of the National Academy of Sciences · Mar 12, 2020Peer-reviewedBiophysics