Transient lagging chromosomes cause primary microcephaly
E. Doria, D. Ivanova, A. Thomas, P. Meraldi
This study shows that transient lagging chromosomes in anaphase, caused by loss of WDR62 and ASPM, lead to impaired cell proliferation and primary microcephaly through Aurora-B-dependent activation of 53BP1 and p21.
bioRxiv · May 2, 2024 · PreprintCell Biology