SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human KATP-induced diabetes trough mitigation of oxidative and ER stress
Z. A. Shyr, Z. Yan, A. Ustione, E. Egan, M. S. Remedi
This study shows SGLT2 inhibitors reduce oxidative and ER stress, restoring β-cell function in early-stage NDM mice but not when β-cell mass and identity are already lost.
bioRxiv · Sep 17, 2021 · PreprintCell Biology